人类大脑中胸腺-脑抗原的检测及分子特征分析。
Detection and molecular characterization of the thymus-brain antigen in human brain.
作者信息
Arndt R, Stark R, Thiele H G
出版信息
Immunology. 1977 Jul;33(1):101-7.
Abstract
Anti-human brain sera were found to contain antibodies reacting with determinants present on murine thymocyte plasma membranes. This determinant is borne by the thymocyte-brain antigen of mouse thymocytes. The non species-specific determinant of the thymocyte-brain system is detectable on the thymocyte-brain antigen of human and mouse brain in comparable amounts. In contrast to these findings, the allogenic Thy-1 and the species-specific determinant of this system were only found on the thymocyte-brain antigen of mouse brain but not on the corresponding antigen of human brain. The molecular weight, Stokes radius and diffusion coefficient of the thymocyte-brain antigen of human and mouse brain are in good accordance with the data estimated for the corresponding antigen of murine thymocytes.
摘要
发现抗人脑血清含有与鼠胸腺细胞质膜上存在的决定簇发生反应的抗体。该决定簇由小鼠胸腺细胞的胸腺细胞-脑抗原携带。胸腺细胞-脑系统的非种属特异性决定簇在人和小鼠脑的胸腺细胞-脑抗原上能以相当的量被检测到。与这些发现相反，同种异体Thy-1和该系统的种属特异性决定簇仅在小鼠脑的胸腺细胞-脑抗原上被发现，而在人脑的相应抗原上未被发现。人和小鼠脑的胸腺细胞-脑抗原的分子量、斯托克斯半径和扩散系数与针对鼠胸腺细胞相应抗原估计的数据高度一致。
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