Mansour A B, Desjeux J F
Arch Fr Pediatr. 1981 Dec;38 Suppl 1:823-8.
We examined the influence of malnutrition on intestinal response to glucose in experimental cholera. Water, electrolytes, and glucose fluxes were directly measured, in isolated ligated loops of rat jejunum. Intestinal loops were filled with Ringer added with either mannitol (30 mM), glucose (30 mM), cholera toxin (TC), or a combination of these three components. The results are as follows: 1. Malnutrition has an effect on basal absorption rate, intestinal response to TC and also to glucose. 2. The secretory effect of cholera toxin is altered by the type of malnutrition, the animal's age and the presence of cholera toxin. 3-0 methyl-glucose, a non-metabolised glucose analogue, has essentially the effect of glucose. The effects produced on water fluxes are also found for Na, K, Cl, HCO3 and glucose fluxes. The relationships between water, glucose, and Na fluxes are not influenced by the different experimental conditions. These results indicate that the intestinal response to glucose in experimental cholera is strongly dependent on the type of malnutrition, the animal's age and the presence of cholera toxin.
我们研究了营养不良对实验性霍乱中肠道对葡萄糖反应的影响。在大鼠空肠的离体结扎肠袢中直接测量水、电解质和葡萄糖通量。肠袢中填充含有甘露醇（30 mM）、葡萄糖（30 mM）、霍乱毒素（TC）或这三种成分组合的林格液。结果如下：1. 营养不良对基础吸收率、肠道对TC以及对葡萄糖的反应均有影响。2. 霍乱毒素的分泌作用因营养不良类型、动物年龄以及霍乱毒素的存在而改变。3 - O - 甲基葡萄糖，一种非代谢性葡萄糖类似物，具有与葡萄糖基本相同的作用。对水通量产生的影响在Na、K、Cl、HCO3和葡萄糖通量中也有发现。水、葡萄糖和Na通量之间的关系不受不同实验条件的影响。这些结果表明，实验性霍乱中肠道对葡萄糖的反应强烈依赖于营养不良类型、动物年龄以及霍乱毒素的存在。
