Best-Belpomme M, Ropp M
Eur J Biochem. 1982 Jan;121(2):349-55. doi: 10.1111/j.1432-1033.1982.tb05793.x.
Clones sensitive or resistant to ecdysterone and cultured in vitro were isolated from established cell line of Drosophila melanogaster. Ecdysterone (20-hydroxyecdysone), a hormonal steroid of critical importance in insect physiology, induces catalase activity in the sensitive clones. This catalase induction does not occur in clones known to be resistant to the the hormone. The important role of catalase as a scavenger for H2O2 in the aerobic cells (Drosophila cells in culture are consuming oxygen) led to the demonstration of catalatic properties of this induced enzyme. The peroxidatic property of catalase, useful in alcohol metabolism, was the reason for showing that ethanol can also induce catalase in Drosophila cells.
从黑腹果蝇已建立的细胞系中分离出对蜕皮激素敏感或抗性的克隆，并进行体外培养。蜕皮激素（20-羟基蜕皮酮）是昆虫生理学中至关重要的一种激素类固醇，可在敏感克隆中诱导过氧化氢酶活性。在已知对该激素具有抗性的克隆中不会发生这种过氧化氢酶诱导现象。过氧化氢酶作为需氧细胞中H2O2清除剂的重要作用（培养中的果蝇细胞正在消耗氧气）导致了这种诱导酶催化特性的证明。过氧化氢酶在酒精代谢中有用的过氧化物酶特性是表明乙醇也能在果蝇细胞中诱导过氧化氢酶的原因。
