对BALB/c肿瘤的交叉反应性细胞毒性T淋巴细胞反应的遗传控制
Genetic control of cross-reactive cytotoxic T-lymphocyte responses to a BALB/c tumor.
作者信息
Russell J H, Dobos C B, Graff R J, Taylor B A
出版信息
Immunogenetics. 1981;14(3-4):263-72. doi: 10.1007/BF00342195.
PMID:6800944
Abstract
Using a segregation analysis we have determined that the cross-reactive response to the DBA/2 tumor P815 by CTL from BALB/c mice immunized with a BALB/c plasmacytoma (MOPC-167) is controlled by a single gene. The gene responsible is closely linked to the dilute coat color locus on chromosome 9. In contrast, the cross-reactive response to the DBA/2 tumor L5178Y by DBA/2 anti-MOPC-167 CTL appears to be controlled by two or more genes.
摘要
通过分离分析，我们确定用BALB/c浆细胞瘤（MOPC-167）免疫的BALB/c小鼠的细胞毒性T淋巴细胞（CTL）对DBA/2肿瘤P815的交叉反应性应答由单个基因控制。相关基因与9号染色体上的淡化毛色基因座紧密连锁。相比之下，DBA/2抗MOPC-167 CTL对DBA/2肿瘤L5178Y的交叉反应性应答似乎由两个或更多基因控制。
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