Upg-2：一种位于小鼠1号染色体上的尿胃蛋白酶原变体。

Upg-2: a urinary pepsinogen variant located on chromosome 1 of the mouse.

作者信息

Szymura J M, Taylor B A, Klein J

出版信息

Biochem Genet. 1982 Dec;20(11-12):1211-9. doi: 10.1007/BF00498944.

Abstract

Acrylamide gel electrophoresis of mouse urine distinguishes two groups of pepsinogens, the fast-migrating group A and the slow-migrating group B. Inbred mouse strains fall into two categories with respect to group B pepsinogens, one expressing a single-banded and the other a double-banded phenotype. This variation is controlled by a single locus, urinary pepsinogen-2 or Upg-2, which has at least two alleles, Upg-2s and Upg-2d. Typing of recombinant inbred strains suggests that the location of the Upg-2 locus is on chromosome 1, in the vicinity of loci coding for other peptidases, namely, Pep-2 and Rnr, and of the Acf-1 locus.

摘要

小鼠尿液的丙烯酰胺凝胶电泳可区分两组胃蛋白酶原，即迁移速度快的A组和迁移速度慢的B组。就B组胃蛋白酶原而言，近交系小鼠品系分为两类，一类表现为单带表型，另一类表现为双带表型。这种变异由单个基因座控制，即尿胃蛋白酶原-2或Upg-2，它至少有两个等位基因，Upg-2s和Upg-2d。重组近交系的分型表明，Upg-2基因座位于1号染色体上，靠近编码其他肽酶的基因座，即Pep-2和Rnr，以及Acf-1基因座。