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铟-111标记血小板的扰动角关联研究

Perturbed angular correlation studies of 111In-labelled platelets.

作者信息

Pandian S, Mathias C J, Welch M J

出版信息

Int J Appl Radiat Isot. 1982 Jan;33(1):33-7. doi: 10.1016/0020-708x(82)90203-4.

DOI:10.1016/0020-708x(82)90203-4
PMID:6800963
Abstract

Indium-111, as the 8-hydroxyquinoline and acetylacetone complexes, has been used to label cellular blood components. Because of the gamma-ray cascade emitted following the decay of indium-111, perturbed angular correlation studies can be used to investigate the environment of the indium nucleus. Perturbed angular correlation studies have been carried out on the indium at various steps in the procedure used to label platelets with indium using both 8-hydroxyquinoline and acetylacetone as the ligand. Similar values of the integral correlation coefficient were obtained in both cases, suggesting identical labeling mechanisms. Following lysis of the platelets the values of (G22(infinity)) changed, suggesting that the intracellular complex is relatively weak.

摘要

铟-111作为8-羟基喹啉和乙酰丙酮配合物,已被用于标记细胞血液成分。由于铟-111衰变后会发射γ射线级联,因此可以利用扰动角关联研究来探究铟原子核的环境。在用8-羟基喹啉和乙酰丙酮作为配体标记血小板的过程中,已在各个步骤对铟进行了扰动角关联研究。在两种情况下都获得了相似的积分关联系数值,这表明标记机制相同。血小板裂解后,(G22(无穷大))的值发生了变化,这表明细胞内的配合物相对较弱。

相似文献

1
Perturbed angular correlation studies of 111In-labelled platelets.铟-111标记血小板的扰动角关联研究
Int J Appl Radiat Isot. 1982 Jan;33(1):33-7. doi: 10.1016/0020-708x(82)90203-4.
2
Cell labelling and cell damage with indium-111 acetylacetone-an alternative to indium 111 oxine.用铟-111乙酰丙酮进行细胞标记和细胞损伤——铟-111草酸盐的替代方法
Br J Radiol. 1981 Jul;54(643):597-601. doi: 10.1259/0007-1285-54-643-597.
3
The comparison of 8-hydroxyquinoline, tropolone, and acetylacetone as mediators in the labelling of polymorphonuclear leucocytes with indium-111: a functional study.8-羟基喹啉、托酚酮和乙酰丙酮作为用铟-111标记多形核白细胞的介质的比较:一项功能研究。
Eur J Nucl Med. 1982;7(2):73-6. doi: 10.1007/BF00251647.
4
Intrahepatic kinetics of indium-111-labelled platelets.铟 - 111标记血小板的肝内动力学
Thromb Haemost. 1985 Oct 30;54(3):595-8.
5
Preparation of a viable population of indium-111-labelled human blood platelets.铟-111标记的人血小板活细胞群的制备。
Thromb Haemost. 1980 Feb 29;42(5):1473-82.
6
Application of the sum peak method to determine the perturbed angular correlation parameters in biological specimens.求和峰法在生物样品中确定扰动角关联参数的应用。
Int J Rad Appl Instrum A. 1988;39(2):131-4. doi: 10.1016/0883-2889(88)90158-x.
7
Labeling of human platelets with [111In) 8-hydroxyquinoline.用[111铟]8-羟基喹啉标记人血小板。
J Nucl Med. 1979 Jun;20(6):524-31.
8
Radionuclide distribution following injection of 111Indium-labelled platelets.注射111铟标记血小板后的放射性核素分布。
Br J Haematol. 1980 Dec;46(4):595-602. doi: 10.1111/j.1365-2141.1980.tb06017.x.
9
Comparison of [111In]oxine and [111In]Acetylacetone for the labeling of cells: in vivo and in vitro biological testing.用于细胞标记的[111铟]喹啉和[111铟]乙酰丙酮的比较:体内和体外生物学测试
Int J Appl Radiat Isot. 1982 Apr;33(4):304. doi: 10.1016/0020-708x(82)90033-3.
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Indium-III: a new radionuclide label for studying human platelet kinetics.铟-III:一种用于研究人体血小板动力学的新型放射性核素标记物。
Br J Haematol. 1979 Aug;42(4):613-22. doi: 10.1111/j.1365-2141.1979.tb01174.x.