致幻剂作为辨别刺激物：4-甲氧基二甲基色胺和5-甲氧基二甲基色胺与其甲硫基类似物的比较。

Hallucinogens as discriminative stimuli: a comparison of 4-OMe DMT and 5-OMe DMT with their methythio counterparts.

作者信息

Glennon R A, Young R, Benington F, Morin R D

出版信息

Life Sci. 1982 Feb 1;30(5):465-7. doi: 10.1016/0024-3205(82)90463-5.

Abstract

Rats, trained to discriminate 1.5 mg/kg of the hallucinogenic agent 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT) from saline in a two-lever drug discrimination task, were challenged with various doses of the 4-methoxy, 4-methylthio and 5-methylthio derivatives of DMT. The 5-OMe DMT cue was found to generalize to all three of these agents; the order of potency is 5-OMe greater than 5-SMe greater than 4-OMe greater than 4-SMe DMT.

摘要

在一项双杠杆药物辨别任务中，训练大鼠从盐水中辨别出1.5毫克/千克的致幻剂5-甲氧基-N，N-二甲基色胺（5-OMe DMT），然后用不同剂量的DMT的4-甲氧基、4-甲硫基和5-甲硫基衍生物对其进行挑战。发现5-OMe DMT线索可推广到所有这三种物质；效力顺序为5-OMe大于5-SMe大于4-OMe大于4-SMe DMT。