Kerridge S
Mol Gen Genet. 1981;184(3):519-25. doi: 10.1007/BF00352532.
The morphology and genetical characteristics of a new dominant homoeotic mutation, called Distal into proximal (Dipr), are described. Dipr causes two main abnormalities, both of which are specific to distal regions of the adult appendages (i.e. the wing, haltere, legs, antenna, and proboscis); first that distal parts are reduced in size and second that the patterns found distally resemble those normally localised in more proximal parts. The mutation maps to the right arm of chromosome 3 and is associated with an inversion with breakpoints in 84D and 84F. Analysis of revertants of Dipr show that the right breakpoint of In(3R)Dipr is the one responsible for the mutant phenotype. Complementation analyses of Dipr revertants and dosage studies of Dipr with different doses of Dipr+ indicate that the mutant is a hypermorph affecting the normal expression of a gene localised in 84F. The developmental significance of the mutation is discussed.
本文描述了一种名为“远端到近端（Dipr）”的新显性同源异型突变的形态学和遗传学特征。Dipr导致两个主要异常，这两个异常均特定于成虫附肢的远端区域（即翅膀、平衡棒、腿、触角和喙）；首先，远端部分尺寸减小，其次，在远端发现的图案类似于通常位于更近端部分的图案。该突变定位于3号染色体右臂，并与一个在84D和84F处有断点的倒位相关。对Dipr回复体的分析表明，In(3R)Dipr的右断点是导致突变表型的原因。对Dipr回复体的互补分析以及用不同剂量的Dipr+对Dipr进行的剂量研究表明，该突变体是一个超形态突变，影响位于84F的一个基因的正常表达。本文还讨论了该突变在发育方面的意义。
