Hoffman W E, Albrecht R F, Miletich D J
Stroke. 1982 Mar-Apr;13(2):225-8. doi: 10.1161/01.str.13.2.225.
Cerebrovascular effects of intravenous (iv) nitroglycerin (NTG) infusions were tested in four month old spontaneously hypertensive rats (SHR) and Wistar Kyoto controls (WKY). Cerebral blood flow (CBF) changes were measured during iv NTG infusion in ventilated, halothane anesthetized rats using radioactive microspheres. In control WKY rats given isotonic saline infusions instead of NTG, blood pressure and CBF did not change over 3 microsphere injections. When blood pressure was decreased to 65 and then 45 torr with iv NTG infusions, CBF was maintained or increased in both SHR and WKY. There was no difference in response between SHR and WKY. These results support other reports that NTG has direct cerebrovasodilating effects, and indicate that this action will maintain adequate CBF in hypertensive as well as normotensive subjects to pressures below 50 torr.
在4月龄的自发性高血压大鼠（SHR）和Wistar Kyoto对照大鼠（WKY）中测试了静脉输注硝酸甘油（NTG）的脑血管效应。在使用放射性微球对经通气、氟烷麻醉的大鼠静脉输注NTG期间，测量脑血流量（CBF）变化。在给予等渗盐水输注而非NTG的对照WKY大鼠中，在3次微球注射过程中血压和CBF均未改变。当通过静脉输注NTG将血压降至65然后45托时，SHR和WKY的CBF均维持或增加。SHR和WKY之间的反应没有差异。这些结果支持了其他报告，即NTG具有直接的脑血管舒张作用，并表明这种作用将在高血压和正常血压受试者中将CBF维持至低于50托的压力水平时保持充足。
