Leão G J, Zaterka S, Neves D P, Bettarello A
Acta Gastroenterol Latinoam. 1981;11(2):273-8.
In order to evaluate the acid secretory pattern in patients with Chagas' Disease when compared to control subjects, the following tests were performed; a) Basal Secretion, b) Acid output after increasing doses of I.V. Pentagastrin (1, 2, 4 and 8 micrograms/Kg-h); c) I.V. Pentagastrin (P) plus a background of subthreshold doses of Urecholine (U) (40 micrograms/Kg-h); d) Calcium infusion test (4 mg of Ca++/Kg-h). The histological aspects of the antral and fundic mucosa was studied on 11 CD patients through samples obtained during gastroscopy. Basal, Pentagastrin stimulated acid secretion and Ca++ stimulated secretion were statistically lower in CD patients when compared to controls. Association of P + U resulted in a higher acid response in 4 out of 8 CD patients but, the mean result of the group was not statistically significant. These results suggest that the lower basal and stimulated acid response of CD patients is related to a decreased sensitivity of the parietal cell. This lower sensitivity is probably dependent on vagal blockage as a consequence of the intramural nerve destruction. The possibility of a smaller stomach and consequently small parietal cell population could not be ruled out in this investigation. However this possibility seems very unprobable to the authors.
为了评估恰加斯病患者与对照受试者相比的胃酸分泌模式，进行了以下测试：a）基础分泌；b）静脉注射递增剂量的五肽胃泌素（1、2、4和8微克/千克·小时）后的胃酸分泌量；c）静脉注射五肽胃泌素（P）加阈下剂量的乌拉胆碱（U）（40微克/千克·小时）作为背景；d）钙输注试验（4毫克钙++/千克·小时）。通过胃镜检查获取的样本，对11例恰加斯病患者的胃窦和胃底黏膜的组织学特征进行了研究。与对照组相比，恰加斯病患者的基础胃酸分泌、五肽胃泌素刺激的胃酸分泌和钙++刺激的胃酸分泌在统计学上较低。在8例恰加斯病患者中，4例患者的P + U联合用药导致了更高的胃酸反应，但该组的平均结果在统计学上不显著。这些结果表明，恰加斯病患者基础胃酸分泌和刺激胃酸分泌较低与壁细胞敏感性降低有关。这种较低的敏感性可能取决于壁内神经破坏导致的迷走神经阻滞。在这项研究中，不能排除胃较小从而壁细胞数量较少的可能性。然而，作者认为这种可能性非常小。
