Padovan W, Godoy R A, Meneghelli U G, Dantas R O, Oliveira R B, Troncon L E
Digestion. 1982;23(1):48-56. doi: 10.1159/000198709.
Gastric acid and pepsin secretory responses to graded doses of pentagastrin were measured in 12 Chagas' disease patients and 18 control subjects, and in 7 Chagas' disease patients and 6 controls the study was repeated with an infusion of bethanecol. Calculated maximal outputs of acid and pepsin (Vmax) and responsiveness (D50) of the acid- and pepsin-secreting cells to pentagastrin were lower in the chagasics. Bethanecol had no significant effect on pentagastrin-stimulated gastric secretions in controls. The impairment of responsiveness of the gastric secretory cells in Chagas' disease patients was fully corrected by bethanecol.
在12例恰加斯病患者和18例对照受试者中测量了胃酸和胃蛋白酶对不同剂量五肽胃泌素的分泌反应，并在7例恰加斯病患者和6例对照中重复进行了此项研究，此次采用了氨甲酰甲胆碱输注法。恰加斯病患者的酸和胃蛋白酶计算最大分泌量（Vmax）以及酸分泌细胞和胃蛋白酶分泌细胞对五肽胃泌素的反应性（D50）较低。氨甲酰甲胆碱对对照组中五肽胃泌素刺激的胃分泌无显著影响。氨甲酰甲胆碱完全纠正了恰加斯病患者胃分泌细胞反应性的损害。
