Grauel E L, Müller S, Gross J, Syllm-Rapoport I
Acta Haematol. 1982;67(2):102-8. doi: 10.1159/000207034.
The adaptation of cell physiological parameters of erythrocytes of the newborn to erythrocytes in later life was studied by cell separation in an isopycnic dextran density gradient. The cell characteristics during the first trimester of life were followed by repeated determinations. The mean cellular haemoglobin concentration of the lightest cells is remarkably less than that of the cells of median density. This is probably due to the ongoing synthesis of haemoglobin in reticulocytes, which are highly concentrated in the top fractions. It was shown that the young cells released from the bone marrow become progressively smaller during this period with a decrease of mean cellular volume (MCV) from 104 micrometer3 at birth to 85 micrometer3 at the end of the first trimester. It has been established that this process commences during the first week of life. No difference concerning the alterations of cell parameters, especially MCV, in premature and mature infants was found. It is therefore probable that these alterations are due to changes in the external milieu following birth.
通过在等密度葡聚糖密度梯度中进行细胞分离，研究了新生儿红细胞的细胞生理参数向成年后红细胞的适应性。通过反复测定跟踪生命头三个月期间的细胞特征。最轻细胞的平均细胞血红蛋白浓度明显低于中等密度细胞的浓度。这可能是由于网织红细胞中血红蛋白的持续合成，网织红细胞高度集中在顶部组分中。结果表明，在此期间从骨髓释放的年轻细胞逐渐变小，平均细胞体积（MCV）从出生时的104立方微米降至头三个月末的85立方微米。已经确定这个过程在出生后的第一周开始。未发现早产儿和足月儿在细胞参数，尤其是MCV的变化方面存在差异。因此，这些变化很可能是由于出生后外部环境的改变所致。
