肾脏疾病中尿胰蛋白酶抑制剂和尿激酶的活性

Urinary trypsin inhibitor and urokinase activities in renal diseases.

作者信息

Toki N, Sumi H

出版信息

Acta Haematol. 1982;67(2):109-13. doi: 10.1159/000207035.

DOI:10.1159/000207035

Abstract

Using an improved method of determination, urinary trypsin inhibitor (UTI) activities were assayed in relation to urokinase (UK) activities in a large group of patients with various renal diseases. In normal subjects (n = 50), the mean 24-hour values of the UTI and UK activities were 4.29 +/- 1.44 U/ml and 9.80 +/- 3.81 IU/ml, respectively. Data for renal diseases such as renal stone, hydronephrosis, renal cancer, and chronic glomerulonephritis (UTI, 5.51 +/- 2.29 U/ml (p less than 0.005) and UK, 6.88 +/- 2.64 IU/ml (p less than 0.001); n = 40), and particularly uremia (UTI, 9.90 +/- 5.68 U/ml (p less than 0.001) and UK, 3.85 +/- 2.36 IU/ml (p less than 0.001); n = 30), showed that the UTI level was increased whereas the UK level was decreased. The UTI/UK ratio more clearly demonstrated the difference between these diseases.

摘要

采用一种改进的测定方法，在一大组患有各种肾脏疾病的患者中，对尿胰蛋白酶抑制剂（UTI）活性与尿激酶（UK）活性进行了测定。在正常受试者（n = 50）中，UTI和UK活性的24小时平均值分别为4.29±1.44 U/ml和9.80±3.81 IU/ml。肾结石、肾积水、肾癌和慢性肾小球肾炎等肾脏疾病的数据（UTI，5.51±2.29 U/ml（p<0.005），UK，6.88±2.64 IU/ml（p<0.001）；n = 40），特别是尿毒症的数据（UTI，9.90±5.68 U/ml（p<0.001），UK，3.85±2.36 IU/ml（p<0.001）；n = 30）显示，UTI水平升高而UK水平降低。UTI/UK比值更清楚地显示了这些疾病之间的差异。