Kearns G L, Fischer T J, Hunter R H
Ann Allergy. 1982 Feb;48(2):71-4.
Analyses of 90 admissions to the Cincinnati Children's Hospital Center, Cincinnati, Ohio, were used to assess the effects of the routine availability of serum theophylline determinations (STD) in treating acute in-hospital asthma over three one-year review periods coinciding with the relative availability of STD. Significant differences were found between the first and third periods for the mean outpatient theophylline dose used on admission, the mean initial in-hospital intravenous dose, the mean initial oral dose during admission and the mean oral discharge dose. No statistical differences were noted in the length of hospital stay, duration of intravenous therapy or report of theophylline toxicity (despite the use of larger theophylline doses). Utilization of STD must be guided by cost-effective pharmacokinetic principles.
对俄亥俄州辛辛那提市辛辛那提儿童医院中心90例入院病例进行分析，以评估在三个为期一年的审查期内，血清茶碱测定（STD）的常规可用性在治疗急性院内哮喘方面的效果，这三个审查期与STD的相对可用性一致。在入院时使用的平均门诊茶碱剂量、平均初始院内静脉剂量、入院期间的平均初始口服剂量和平均口服出院剂量方面，第一期和第三期之间存在显著差异。在住院时间、静脉治疗持续时间或茶碱毒性报告方面（尽管使用了更大的茶碱剂量）未发现统计学差异。STD的使用必须以具有成本效益的药代动力学原则为指导。
