γ-氨基丁酸（GABA）在慢性肾衰竭患者促性腺激素分泌调节中的调节作用。

Modulatory role of gamma-aminobutyric acid (GABA) in the regulation of gonadotropin secretion in patients with chronic renal failure.

作者信息

Elias A N, Pahl M, Stone S, Vaziri N D, Valenta L J

出版信息

Int J Artif Organs. 1982 Jan;5(1):13-6.

Abstract

The role of gamma-aminobutyric acid (GABA) in the regulation of gonadotropin secretion in renal failure, was studied in 5 patients with chronic renal failure who were on maintenance dialysis. Di-n-propylacetic acid (valproic acid-VA), a GABA-transaminase inhibitor which has been shown to increase brain GABA levels, was used in the study. VA produced no significant change in the basal serum LH and FSH concentrations, or in E2 or T concentrations in the renal failure patients, or the E2 and P concentrations in normal controls, but augmented the delta LH (maximum increment above baseline) and delta FSH response to LH-RH. delta LH rose from 30.4 +/- 12.7 mIU/ml (mean +/- SD) to 41.1 +/- 16.8 mIU/ml (p less than 0.01) after VA, while delta FSH rose from 2.8 +/- 1.8 mIU/ml to 3.8 +/- 1.6 mIU/ml (p less than 0.05). The findings support a modulatory role for GABA in gonadotropin secretion in chronic renal failure.

摘要

在5例接受维持性透析的慢性肾衰竭患者中，研究了γ-氨基丁酸（GABA）在肾衰竭患者促性腺激素分泌调节中的作用。研究中使用了二正丙基乙酸（丙戊酸-VA），一种已被证明可提高脑内GABA水平的GABA转氨酶抑制剂。VA对肾衰竭患者的基础血清促黄体生成素（LH）和促卵泡生成素（FSH）浓度、E2或T浓度，以及正常对照者的E2和孕酮（P）浓度均无显著影响，但增强了LH对促性腺激素释放激素（LH-RH）的LH变化值（高于基线的最大增加值）和FSH反应。VA用药后，LH变化值从30.4±12.7 mIU/ml（平均值±标准差）升至41.1±16.8 mIU/ml（p<0.01），而FSH变化值从2.8±1.8 mIU/ml升至3.8±1.6 mIU/ml（p<0.05）。这些发现支持GABA在慢性肾衰竭患者促性腺激素分泌中起调节作用。