Coupland R E, Kent C, Kent S E
J Endocrinol. 1982 Mar;92(3):433-42. doi: 10.1677/joe.0.0920433.
An attempt has been made to determine the relative functional activities of adrenal and extra-adrenal chromaffin tissue during the neonatal phase and up to 1 week of age using young rabbits and guinea-pigs whose main extra-adrenal abdominal para-aortic chromaffin bodies are respectively non-innervated and innervated. Amine synthesis and storage were followed by assay and autoradiography after a single intraperitoneal injection of L-[2,5,6-3H]DOPA and the findings correlated with amine content as assessed by high performance liquid chromatography and by volume of tissue. The results indicate that in the guinea-pig, in spite of differences in proportions of adrenaline and noradrenaline in the adrenal gland and para-aortic body (PAB), the loss of labelled catecholamines from the innervated PAB closely follows that from the adrenal medulla, suggesting that both participate in normal sympathoadrenal activity. By comparison, in the rabbit the PAB shows only a minimal decreased labelled amine during the first week of life during which period the amine content and concentration of the PAB doubles: the functional significance of this non-innervated extra-adrenal chromaffin tissue, which persists throughout life, has still to be determined.
研究人员利用幼兔和豚鼠，试图确定新生期至1周龄期间肾上腺和肾上腺外嗜铬组织的相对功能活性，这些幼兔和豚鼠的主要肾上腺外腹主动脉旁嗜铬体分别是无神经支配和有神经支配的。单次腹腔注射L-[2,5,6-³H]多巴后，通过测定和放射自显影追踪胺的合成和储存情况，并将这些结果与通过高效液相色谱法和组织体积评估的胺含量相关联。结果表明，在豚鼠中，尽管肾上腺和主动脉旁体（PAB）中肾上腺素和去甲肾上腺素的比例存在差异，但有神经支配的PAB中标记的儿茶酚胺的损失与肾上腺髓质中的损失密切相关，这表明两者都参与正常的交感肾上腺活动。相比之下，在兔子中，PAB在出生后的第一周内仅显示出标记胺的最小减少，在此期间PAB的胺含量和浓度增加了一倍：这种终生存在的无神经支配的肾上腺外嗜铬组织的功能意义仍有待确定。
