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人胎儿腹部副神经节中含血管活性肠肽(VIP)神经纤维存在的免疫组织化学证据。

Immunohistochemical evidence for the occurrence of vasoactive intestinal polypeptide (VIP)-containing nerve fibres in human fetal abdominal paraganglia.

作者信息

Hervonen A, Linnoila I, Tainio H, Vaalasti A, Mascorro J A

机构信息

Department of Biomedical Sciences and Public Health, University of Tampere, Finland.

出版信息

J Anat. 1985 Dec;143:121-8.

PMID:3870718
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1166430/
Abstract

The abdominal paraganglia in man represent a major source of catecholamines, and perhaps peptide hormones, during the fetal period. The nature of the innervation of the abdominal paraganglia was studied immunohistochemically by utilising antibodies to vasoactive intestinal polypeptide, enkephalin, substance-P and somatostatin. The paraganglia showed an abundant network of VIP-immunoreactive fibres, and similar nerve fibres were found within nerve bundles of the preaortic sympathetic plexus. Occasionally, VIP-immunoreactive fibres were seen within the prevertebral ganglia, but stained cell bodies were never observed. It may be suggested that VIP-containing nerves could regulate a secretory response from fetal human abdominal paraganglia.

摘要

在人类胎儿期,腹部副神经节是儿茶酚胺以及可能的肽类激素的主要来源。利用抗血管活性肠肽、脑啡肽、P物质和生长抑素的抗体,通过免疫组织化学方法研究了腹部副神经节的神经支配性质。副神经节显示出丰富的血管活性肠肽免疫反应性纤维网络,并且在主动脉前交感神经丛的神经束内也发现了类似的神经纤维。偶尔,在椎前神经节内可见血管活性肠肽免疫反应性纤维,但从未观察到染色的细胞体。可以推测,含血管活性肠肽的神经可能调节人类胎儿腹部副神经节的分泌反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27a1/1166430/b1b12edd1a5a/janat00190-0125-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27a1/1166430/5a415fef39f6/janat00190-0123-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27a1/1166430/b1b12edd1a5a/janat00190-0125-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27a1/1166430/5a415fef39f6/janat00190-0123-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27a1/1166430/c74bf23ea364/janat00190-0123-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27a1/1166430/488ebd13a289/janat00190-0123-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27a1/1166430/498a348badce/janat00190-0123-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27a1/1166430/210086c8cf34/janat00190-0123-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27a1/1166430/b1b12edd1a5a/janat00190-0125-a.jpg

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本文引用的文献

1
Post-natal fate of the abdominal para-aortic bodies in man.人类腹主动脉旁体的产后命运
J Anat. 1954 Oct;88(4):455-64.
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The prenatal development of the abdominal para-aortic bodies in man.人类腹主动脉旁体的产前发育
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Electron-microscopic localization of enkephalin-like imnmunoreactivity in axon terminals of human sympathetic ganglia.脑啡肽样免疫反应性在人交感神经节轴突终末的电镜定位
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Immunocytochemical identification of neuroendocrine markers in human cardiac paraganglion-like structures.人心脏副神经节样结构中神经内分泌标志物的免疫细胞化学鉴定
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An immunohistochemical study of human postnatal paraganglia associated with the urinary bladder.一项关于与膀胱相关的人类产后副神经节的免疫组织化学研究。
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The effect of aging on extra-adrenal catecholamine storing cells of the rat.衰老对大鼠肾上腺外儿茶酚胺储存细胞的影响。
Neurobiol Aging. 1984 Summer;5(2):105-10. doi: 10.1016/0197-4580(84)90039-3.
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Neurobiological and neuroendocrine functions of the vasoactive intestinal peptide (VIP).血管活性肠肽(VIP)的神经生物学和神经内分泌功能。
Prog Neurobiol. 1984;22(2):103-29. doi: 10.1016/0301-0082(84)90022-4.
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Fetal catecholamines.胎儿儿茶酚胺
Am J Obstet Gynecol. 1983 Aug 1;146(7):840-55. doi: 10.1016/0002-9378(83)91088-8.
8
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Cell Tissue Res. 1984;236(3):527-40. doi: 10.1007/BF00217219.
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Cell Tissue Res. 1981;214(1):33-42. doi: 10.1007/BF00235142.