Neoplasma. 1982;29(1):19-27.
Effect of adrenalectomy and or thymosin administration on the tumor growth and immunity system were investigated on the models of 7.12-dimethylbenza(a)anthracene(DMBA)-induced mammary neoplasms in rats. Adrenalectomy and thymosin administration resulted in antitumorigenic action, whereas maximal inhibiting effect was achieved after thymosin injection in adrenalectomized animals. The maximal antitumorigenic effect of thymosin in adrenalectomized rats was accompanied by synergistic immunopotentiating effect of thymosin and adrenalectomy. Immunorehabilitation with thymosin and simultaneous correction of hormone production in the adrenal cortex are believed to enhance the effectiveness of therapy in cancer patients.
在7,12-二甲基苯并(a)蒽(DMBA)诱导的大鼠乳腺肿瘤模型上，研究了肾上腺切除术和/或胸腺素给药对肿瘤生长和免疫系统的影响。肾上腺切除术和胸腺素给药产生了抗肿瘤作用，而在肾上腺切除的动物中注射胸腺素后达到了最大抑制效果。胸腺素在肾上腺切除大鼠中的最大抗肿瘤作用伴随着胸腺素和肾上腺切除术的协同免疫增强作用。胸腺素免疫康复以及同时纠正肾上腺皮质激素分泌被认为可提高癌症患者的治疗效果。
