由2-乙氧羰基-4H-3,1-苯并恶嗪-4-酮合成脒腙
Synthesis of amidrazones from 2-ethoxycarbonyl-4H-3,1-benzoxazin-4-one.
作者信息
Osman A N, Botros S
出版信息
Pharmazie. 1982 Jan;37(1):17-8.
PMID:6803255
Abstract
Hydrazine, phenylhydrazine and carboxylic acid hydrazides underwent an addition reaction to the 1,2 double bond of 2-ethoxycarbonyl-4H-3, 1-benzoxazin-4-one with ring opening to give oxalamidrazone derivatives. Preliminary screening of these amidrazones showed that some of the synthesized compounds exhibited antitubercular activity.
摘要
肼、苯肼和羧酸酰肼与2-乙氧羰基-4H-3,1-苯并恶嗪-4-酮的1,2-双键发生加成反应并开环，生成草酰胺腙衍生物。对这些腙的初步筛选表明，一些合成化合物具有抗结核活性。
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