Harrison D C, Irwin W G
Arch Mal Coeur Vaiss. 1981 Dec;74 Spec No:73-7.
In the 1980's, arrhythmias will be treated with new drugs with increasing efficacy and safety. A better understanding of basic biology will provide the framework for the physician to deal with the problem areas presented. Better chemical techniques for assaying plasma concentration of primary drug and metabolite will provide the clinical basis for administering these new agents. The importance of altered protein binding on both the efficacy and safety of drugs will become better understood. Drug interactions will be appreciated for having both a beneficial and harmful effect in certain patient syndromes. Understanding factors which relate to the bioavailability of a drug will no doubt provide clues as to better administration patterns in most patients. The decade of the 1980's will prove exciting for the clinical pharmacologist and the cardiologist as they treat patients with cardiac arrhythmias.
在20世纪80年代，心律失常将采用疗效和安全性不断提高的新药进行治疗。对基础生物学更深入的理解将为医生处理出现问题的领域提供框架。用于测定主要药物和代谢物血浆浓度的更好化学技术将为使用这些新药提供临床依据。蛋白质结合改变对药物疗效和安全性的影响将得到更好的理解。药物相互作用在某些患者综合征中既有有益作用也有有害作用这一点将受到重视。了解与药物生物利用度相关的因素无疑将为大多数患者更好的给药方式提供线索。对于临床药理学家和心脏病学家来说，20世纪80年代在治疗心律失常患者时将是令人兴奋的十年。
