Moynihan M, Petersen I
Dev Biol Stand. 1981;50:243-8.
The use of ELISA to estimate poliovirus antigen concentration has permitted an evaluation of the methodology used in vaccine production and allowed exploration of less wasteful filtration-techniques. The replacement of Seitz-EKS-1B filtration with either Seitz-Supra-EKS or Pall-filtration in the preparation of the vaccine could make a large saving in the total antigen yield, but the results in the safety test excluded their possible use in our process as it stands at the moment.
使用酶联免疫吸附测定法（ELISA）来估计脊髓灰质炎病毒抗原浓度，有助于评估疫苗生产中所使用的方法，并能够探索更节省资源的过滤技术。在疫苗制备过程中，用赛茨-超-EKS过滤器或颇尔过滤器替代赛茨-EKS-1B过滤器，可能会大幅节省总抗原产量，但目前的安全性测试结果排除了它们在我们现有生产流程中的使用可能性。
