Marchildon M B
JPEN J Parenter Enteral Nutr. 1982 Jan-Feb;6(1):25-9. doi: 10.1177/014860718200600125.
Five surgical infants, ages 3 to 30 days, were studied while receiving peripheral total parenteral nutrition for a period of 2 weeks. By a randomized sequence, either 10 or 20% safflower oil emulsion was infused the first week, followed by the alternate solution during the second week. Caloric intake was 80 to 100 cal/kg/day, of which lipids comprised one-third to one-half. No adverse side effects were noted. Eosinophilia developed in three patients, but otherwise no changes in hematologic and biochemical parameters, including liver enzymes, were noted. Weight gain averaged 11.1 g/kg/day during the study period and was similar for the 10 and 20% solutions. Intravenous fluid intake averaged 21 ml/kg/day less during the week of the patients received 20% fluid emulsions. The 20% safflower oil emulsion proved comparable to the 10% solution in both safety and efficacy and enabled significant reduction of fluid intake while maintaining infused caloric levels.
对5名年龄在3至30天的外科手术患儿进行了研究，他们接受了为期2周的外周全胃肠外营养。通过随机序列，第一周输注10%或20%的红花油乳剂，第二周输注另一种溶液。热量摄入为80至100千卡/千克/天，其中脂质占三分之一至二分之一。未观察到不良副作用。3名患者出现嗜酸性粒细胞增多，但其他方面未观察到血液学和生化参数的变化，包括肝酶。在研究期间，体重平均增加11.1克/千克/天，10%和20%的溶液相似。在患者接受20%液体乳剂的那一周，静脉液体摄入量平均每天减少21毫升/千克。20%的红花油乳剂在安全性和有效性方面与10%的溶液相当，并且在维持输注热量水平的同时能够显著减少液体摄入量。
