Gerig H J, Kern F
Anaesthesist. 1982 Feb;31(2):87-9.
80 patients undergoing hip surgery under lumbar epidural block have been studied (double blind) for postoperative analgesia. There were 4 groups, of 20 patients each, who received a single epidural injection of 0 mg, 2 mg or 4 mg morphine in 1 ml of saline added to 6 ml bupivacaine 0.5% or 4 mg morphine in 6 ml saline. In the morphine groups analgesia lasted between 37 and 50 hours. No neurological side-effects or severe respiratory depression have was observed; but a significant rise of paCO2 was found. Other side-effects were nausea/vomiting and the need for catheterisation in about 50% of patients. We conclude, that the indications for epidural analgesia with morphine have to be chosen carefully.
对80例接受腰段硬膜外阻滞下髋关节手术的患者进行了(双盲)术后镇痛研究。共分为4组,每组20例患者,分别接受在1ml生理盐水中加入0mg、2mg或4mg吗啡并与6ml 0.5%布比卡因混合后的单次硬膜外注射,或6ml生理盐水中加入4mg吗啡的注射。吗啡组的镇痛持续时间为37至50小时。未观察到神经副作用或严重呼吸抑制;但发现动脉血二氧化碳分压显著升高。其他副作用为恶心/呕吐,约50%的患者需要导尿。我们得出结论,必须谨慎选择吗啡硬膜外镇痛的适应证。