N-甲酰亚胺硫霉素（MK0787）和阿洛西林与三种氨基糖苷类药物及替卡西林对铜绿假单胞菌的体外比较
In vitro comparison of N-formimidoyl thienamycin (MK0787) and Azlocillin with three aminoglycosides and ticarcillin against Pseudomonas aeruginosa.
作者信息
Matzkowitz A J, Baltch A L, Smith R P, Sutphen N T, Hammer M C, Conroy J V
出版信息
Antimicrob Agents Chemother. 1982 Apr;21(4):685-7. doi: 10.1128/AAC.21.4.685.
Abstract
The activities of N-formimidoyl thienamycin and azlocillin were compared with those of tobramycin, gentamicin, amikacin, and ticarcillin against 175 Pseudomonas aeruginosa isolates, including 24 strains with known mechanisms of resistance to aminoglycosides. The 50% mean inhibitory concentration for azlocillin was lower than for ticarcillin, but the 90% mean inhibitory concentration was similar for both drugs. All susceptible and multidrug-resistant strains were susceptible to N-formimidoyl thienamycin.
摘要
将亚胺硫霉素和阿洛西林的活性与妥布霉素、庆大霉素、阿米卡星和替卡西林针对175株铜绿假单胞菌分离株的活性进行了比较，其中包括24株已知对氨基糖苷类耐药机制的菌株。阿洛西林的平均50%抑制浓度低于替卡西林，但两种药物的平均90%抑制浓度相似。所有敏感和多重耐药菌株对亚胺硫霉素均敏感。
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