Fu K P, Neu H C
Antimicrob Agents Chemother. 1978 Jun;13(6):930-8. doi: 10.1128/AAC.13.6.930.
The activity of azlocillin and mezlocillin, new semisynthetic ureido penicillins, was investigated and compared with that of other known beta-lactam antibiotics. At a concentration of 25 mug/ml, azlocillin inhibited 74% of Enterobacter, 97% of Proteus mirabilis, 64% of Citrobacter, 91% of Pseudomonas aeruginosa, and 82% of Bacteroides strains tested. Mezlocillin inhibited 86% of Shigella, 96% of Enterobacter, 80% of indole-positive Proteus, 88% of Bacteroides, and 63% of Pseudomonas strains tested. Azlocillin was more active against Pseudomonas than was ticarcillin, carbenicillin, or mezlocillin. Mezlocillin was more active than carbenicillin and ampicillin against Escherichia coli, Klebsiella, Enterobacter, Citrobacter, Acinetobacter, Serratia, and Bacteroides. Azlocillin and mezlocillin were less active than cefazolin against beta-lactamase-producing E. coli and Klebsiella strains but more active than cefazolin against Enterobacter, indole-positive Proteus, Acinetobacter, Citrobacter, and Serratia strains. Both compounds showed activity equivalent to that of cefoxitin against Bacteroides isolates. Both agents were destroyed by many of the beta-lactamases from gram-negative organisms.
对新型半合成脲基青霉素阿洛西林和美洛西林的活性进行了研究，并与其他已知的β-内酰胺类抗生素进行了比较。在浓度为25微克/毫升时，阿洛西林抑制了74%的肠杆菌、97%的奇异变形杆菌、64%的柠檬酸杆菌、91%的铜绿假单胞菌以及82%的受试拟杆菌菌株。美洛西林抑制了86%的志贺菌、96%的肠杆菌、80%的吲哚阳性变形杆菌、88%的拟杆菌以及63%的受试假单胞菌菌株。阿洛西林对假单胞菌的活性比替卡西林、羧苄西林或美洛西林更强。美洛西林对大肠杆菌、克雷伯菌、肠杆菌、柠檬酸杆菌、不动杆菌、沙雷菌和拟杆菌的活性比羧苄西林和氨苄西林更强。阿洛西林和美洛西林对产β-内酰胺酶的大肠杆菌和克雷伯菌菌株的活性比头孢唑林弱，但对肠杆菌、吲哚阳性变形杆菌、不动杆菌、柠檬酸杆菌和沙雷菌菌株的活性比头孢唑林强。这两种化合物对拟杆菌分离株的活性与头孢西丁相当。这两种药物都被许多革兰氏阴性菌产生的β-内酰胺酶所破坏。
