莫能菌素抑制软骨细胞中蛋白聚糖的合成，但不抑制透明质酸的合成。
Monensin inhibits synthesis of proteoglycan, but not of hyaluronate, in chondrocytes.
作者信息
Mitchell D, Hardingham T
出版信息
Biochem J. 1982 Jan 15;202(1):249-54. doi: 10.1042/bj2020249.
Abstract
Monensin (10nm-1mum) inhibited the incorporation of [(35)S]sulphate and [(3)H]glucosamine into proteoglycans by rat chondrosarcoma cells, but the incorporation of [(3)H]glucosamine into hyaluronate was unaffected. The results suggest that hyaluronate synthesis occurs in a cell compartment separate from chondroitin sulphate synthesis.
摘要
莫能菌素（10纳米 - 1微米）抑制大鼠软骨肉瘤细胞将[（35）S]硫酸盐和[（3）H]葡糖胺掺入蛋白聚糖，但[（3）H]葡糖胺掺入透明质酸不受影响。结果表明，透明质酸合成发生在与硫酸软骨素合成分开的细胞区室中。
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