1977年以来英国流感嗜血杆菌抗生素耐药性增加：研究小组报告
Increase in antibiotic resistance in Haemophilus influenzae in the United Kingdom since 1977: report of study group.
作者信息
Philpott-Howard J, Williams J D
出版信息
Br Med J (Clin Res Ed). 1982 May 29;284(6329):1597-9. doi: 10.1136/bmj.284.6329.1597.
Abstract
A survey of antibiotic resistance in Haemophilus influenzae was carried out in the United Kingdom with 25 laboratories participating. The incidence of resistance in the 1841 strains examined was: tetracycline 3.1%, ampicillin 6.2%, chloramphenicol 1.03%, trimethoprim 1.4%, and sulphamethoxazole 1.5%. Of the 115 strains resistant to ampicillin, 106 produced beta-lactamase. Seventy-nine strains were capsulate, none of which was chloramphenicol resistant, but nine produced beta-lactamase (11.4%). Comparison of these figures of antibiotic resistance with those from a similar survey performed in 1977 showed a significant increase in resistance of H influenzae to ampicillin, chloramphenicol, and trimethoprim.
摘要
英国开展了一项针对流感嗜血杆菌抗生素耐药性的调查，有25个实验室参与。在所检测的1841株菌株中，耐药发生率如下：四环素3.1%，氨苄西林6.2%，氯霉素1.03%，甲氧苄啶1.4%，磺胺甲恶唑1.5%。在115株对氨苄西林耐药的菌株中，106株产生β-内酰胺酶。79株有荚膜，其中无氯霉素耐药菌株，但9株产生β-内酰胺酶（11.4%）。将这些抗生素耐药性数据与1977年进行的类似调查结果相比较，结果显示流感嗜血杆菌对氨苄西林、氯霉素和甲氧苄啶的耐药性显著增加。
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