Bennett D C
St George's Hospital Medical School, London, UK.
Environ Health Perspect. 1989 Mar;80:49-59. doi: 10.1289/ehp.898049.
Literature is reviewed on the mechanisms of differentiation in mammalian melanoma cells and normal melanocytes. Pigment cells are particularly useful for studies requiring the observation of differentiation in living cells, for example, studies of commitment. Topics discussed include melanin synthesis and other markers of pigment cell differentiation; stochastic models of differentiation and commitment; the lability of early stages of differentiation; extracellular factors affecting pigment cell differentiation, with implications for intracellular controls; the role of proliferation and the cell cycle in differentiation, and the relative roles of changes in transcription, translation, and posttranslational processes.
本文综述了关于哺乳动物黑色素瘤细胞和正常黑素细胞分化机制的文献。色素细胞对于需要观察活细胞分化的研究特别有用，例如，关于细胞定向分化的研究。讨论的主题包括黑色素合成和色素细胞分化的其他标志物；分化和定向分化的随机模型；分化早期阶段的不稳定性；影响色素细胞分化的细胞外因子及其对细胞内调控的影响；增殖和细胞周期在分化中的作用，以及转录、翻译和翻译后过程变化的相对作用。
