苦马豆素通过抑制高尔基体甘露糖苷酶II来抑制复合糖蛋白的生物合成。 - Suppr

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超能文献

Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of Golgi mannosidase II.

作者信息

Tulsiani D R, Harris T M, Touster O

出版信息

J Biol Chem. 1982 Jul 25;257(14):7936-9.

PMID:6806288

Abstract

摘要

相似文献

Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of Golgi mannosidase II.苦马豆素通过抑制高尔基体甘露糖苷酶II来抑制复合糖蛋白的生物合成。

J Biol Chem. 1982 Jul 25;257(14):7936-9.

Asparagine-linked glycoprotein biosynthesis in rat epididymis. Presence of a mannosidase II-like enzyme.大鼠附睾中与天冬酰胺连接的糖蛋白生物合成。一种类甘露糖苷酶II的存在。

Biochem J. 1991 Jul 1;277 ( Pt 1)(Pt 1):213-21. doi: 10.1042/bj2770213.

Marked differences in the swainsonine inhibition of rat liver lysosomal alpha-D-mannosidase, rat liver Golgi mannosidase II, and jack bean alpha-D-mannosidase.苦马豆素对大鼠肝脏溶酶体α-D-甘露糖苷酶、大鼠肝脏高尔基体甘露糖苷酶II和刀豆α-D-甘露糖苷酶的抑制作用存在显著差异。

Arch Biochem Biophys. 1985 Jan;236(1):427-34. doi: 10.1016/0003-9861(85)90643-5.

Swainsonine, a potent mannosidase inhibitor, elevates rat liver and brain lysosomal alpha-D-mannosidase, decreases Golgi alpha-D-mannosidase II, and increases the plasma levels of several acid hydrolases.苦马豆素是一种有效的甘露糖苷酶抑制剂，它能提高大鼠肝脏和脑溶酶体α-D-甘露糖苷酶的活性，降低高尔基体α-D-甘露糖苷酶II的活性，并提高几种酸性水解酶的血浆水平。

Arch Biochem Biophys. 1983 Jul 15;224(2):594-600. doi: 10.1016/0003-9861(83)90247-3.

Substrate specificities of rat kidney lysosomal and cytosolic alpha-D-mannosidases and effects of swainsonine suggest a role of the cytosolic enzyme in glycoprotein catabolism.大鼠肾脏溶酶体和胞质α-D-甘露糖苷酶的底物特异性以及苦马豆素的作用表明胞质酶在糖蛋白分解代谢中发挥作用。

J Biol Chem. 1987 May 15;262(14):6506-14.

Swainsonine induces the production of hybrid glycoproteins and accumulation of oligosaccharides in male reproductive tissues of the rat.苦马豆素诱导大鼠雄性生殖组织中杂合糖蛋白的产生和寡糖的积累。

Biol Reprod. 1990 Jul;43(1):130-8. doi: 10.1095/biolreprod43.1.130.

alpha-D-mannopyranosylmethyl-p-nitrophenyltriazene inhibition of rat liver alpha-D-mannosidases.α-D-甘露吡喃糖基甲基对硝基苯基三氮烯对大鼠肝脏α-D-甘露糖苷酶的抑制作用

Biochim Biophys Acta. 1987 Aug 21;914(3):283-8. doi: 10.1016/0167-4838(87)90287-1.

alpha-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases Ia and IB are the enzymes converting Man9 precursors to Man5 intermediates.大鼠肝脏高尔基体膜的α-D-甘露糖苷酶。甘露糖苷酶II是糖蛋白生物合成中切割GlcNAcMAN5的酶，而甘露糖苷酶Ia和IB是将Man9前体转化为Man5中间体的酶。

J Biol Chem. 1982 Apr 10;257(7):3660-8.

Mechanism and regulation of protein turnover: effect of the alpha-mannosidase inhibitor, swainsonine, on glycoprotein degradation.蛋白质周转的机制与调控：α-甘露糖苷酶抑制剂苦马豆素对糖蛋白降解的影响

Curr Top Cell Regul. 1984;24:229-49. doi: 10.1016/b978-0-12-152824-9.50029-0.

Swainsonine causes the production of hybrid glycoproteins by human skin fibroblasts and rat liver Golgi preparations.苦马豆素可使人皮肤成纤维细胞和大鼠肝脏高尔基体制剂产生杂合糖蛋白。

J Biol Chem. 1983 Jun 25;258(12):7578-85.

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1,4-Dideoxy-1,4-imino-D- and L-lyxitol-based inhibitors bind to Golgi α-mannosidase II in different protonation forms.基于 1,4-二脱氧-1,4-亚氨基-D-和 L-山梨醇的抑制剂以不同的质子化形式结合到高尔基 α-甘露糖苷酶 II 上。

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Small RNAs are modified with N-glycans and displayed on the surface of living cells.小分子 RNA 经过 N-糖基化修饰并展示在活细胞表面。

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