Newman J, Hicks R M
Histopathology. 1977 Mar;1(2):125-35. doi: 10.1111/j.1365-2559.1977.tb01651.x.
Scanning and transmission electron microscopy reveal distinct differences between the appearance of the luminal surface membrane of normal urothelium and those of transitional cell tumours of both human and rat bladder. The luminal surface membrane of the preneoplastic rat urothelium shows features similar to those seen in the fully developed tumour. In human tumour-bearing bladders the urothelium away from the transitional cell tumour is not recognizable as being preneoplastic by light microscopy. However, by scanning or transmission electron microscopy, the luminal membrane in some areas shows changes identical to those in the preneoplastic rat bladder. These observations are in accordance with the clinical behaviour of the urothelium in patients with vesical transitional cell tumours which tend to recur in disparate site. We suggest that scanning electron microscopy of the bladder urothelium away from the tumour may be of prognostic value for indicating the subsequent biological behaviour of the urothelium.
扫描电子显微镜和透射电子显微镜显示，正常尿路上皮腔面细胞膜的外观与人类和大鼠膀胱移行细胞肿瘤的腔面细胞膜外观截然不同。癌前大鼠尿路上皮的腔面细胞膜呈现出与完全发育的肿瘤中所见特征相似的特性。在人类患有肿瘤的膀胱中，远离移行细胞肿瘤的尿路上皮通过光学显微镜无法识别为癌前病变。然而，通过扫描电子显微镜或透射电子显微镜观察，某些区域的腔面膜显示出与癌前大鼠膀胱中相同的变化。这些观察结果与膀胱移行细胞肿瘤患者尿路上皮的临床行为一致，这些肿瘤往往在不同部位复发。我们认为，对远离肿瘤的膀胱尿路上皮进行扫描电子显微镜检查可能对指示尿路上皮随后的生物学行为具有预后价值。
