Shlevin H H
Life Sci. 1982 Apr 12;30(15):1233-46. doi: 10.1016/0024-3205(82)90685-3.
Nitroglycerin, first introduced over a hundred years ago, is now finding wider clinical applications. To a large degree, the renewed interest in the clinical pharmacologic usage of nitroglycerin is due to the availability of new formulations and drug delivery systems. The current review focuses on the physiological and pharmacological actions of nitroglycerin in mammals. Routes of nitroglycerin metabolism, biochemistry and absorption are discussed. The phenomenon of nitroglycerin tolerance is illustrated and related to specific quantitative alterations occurring at the cellular level. The cardiovascular effects of nitroglycerin are discussed in terms of its effects on coronary flow, the myocardium itself, and on the peripheral vasculature. The early speculation of Murrell (3) that nitroglycerin "would probably prove of service in the treatment of angina pectoris ... and other vascular disorders ..." has now been realized.
硝酸甘油于一百多年前首次被引入，如今正得到更广泛的临床应用。在很大程度上，对硝酸甘油临床药理学用途重新产生的兴趣归因于新剂型和药物递送系统的出现。本综述聚焦于硝酸甘油在哺乳动物体内的生理和药理作用。讨论了硝酸甘油的代谢途径、生物化学及吸收情况。阐述了硝酸甘油耐受性现象，并将其与细胞水平发生的特定定量变化相关联。从硝酸甘油对冠状动脉血流、心肌本身以及外周血管系统的影响方面，讨论了其心血管效应。默雷尔（3）早期推测硝酸甘油“可能会被证明对治疗心绞痛……及其他血管疾病……有用”，如今这一推测已成为现实。
