Daly J M, Massar E, Giacco G, Frazier O H, Mountain C F, Dudrick S J, Copeland E M
Ann Surg. 1982 Aug;196(2):203-8. doi: 10.1097/00000658-198208000-00014.
A review of operative therapy in 244 patients with esophageal cancer from 1960 to 1980 was done to evaluate the impact of TPN in 72 patients treated from 1973 to 1980 with 43 non-TPN patients treated during the same period and to 129 patients operated upon before 1973. Mean age, sex distribution, site, stage, and treatment of the disease were similar for the two study groups. The TPN group lost less weight during treatment (3 lbs vs. 11 lbs) and had fewer overall complications postoperatively (24% vs. 41%). Significant reductions in major wound, infectious, and postoperative complications were noted in these patients who received at least 5 days of preoperative TPN compared with postoperative TPN or the non-TPN groups (4% vs. 24% and 23%). Malnourished esophageal cancer patients can more safely undergo aggressive operative therapy and radiation treatment when adequate perioperative nutritional support is added to the treatment armamentarium.
对1960年至1980年间244例食管癌患者的手术治疗进行了回顾，以评估全肠外营养（TPN）对1973年至1980年间接受治疗的72例患者的影响，同期有43例未接受TPN治疗的患者，以及1973年前接受手术的129例患者。两个研究组在疾病的平均年龄、性别分布、部位、分期和治疗方面相似。TPN组在治疗期间体重减轻较少（3磅对11磅），术后总体并发症较少（24%对41%）。与术后接受TPN或未接受TPN的组相比，术前至少接受5天TPN的患者，其主要伤口、感染和术后并发症显著减少（4%对24%和23%）。当在治疗手段中增加充分的围手术期营养支持时，营养不良的食管癌患者可以更安全地接受积极的手术治疗和放射治疗。
