Venutti P, Ferretti C, Portaleone P
Experientia. 1982 May 15;38(5):601-3. doi: 10.1007/BF02327072.
The 'in vitro' activity of ergotamine, dihydroergocristine, dihydroergocornine and dihydroergocryptine on the phosphodiesterase system at low and high Km in several rat brain areas was examined. These drugs were found to exert an inhibitory effect in all the areas examined with regard to both systems, and particularly on low substrate concentration phosphodiesterases.
研究了麦角胺、二氢麦角隐亭、二氢麦角柯宁碱和二氢麦角环肽在几种大鼠脑区中对低Km和高Km磷酸二酯酶系统的“体外”活性。发现这些药物对所研究的所有脑区的这两种系统均有抑制作用，尤其对低底物浓度的磷酸二酯酶。
