Saiani L, Trabucchi M, Tonon G C, Spano P F
Neurosci Lett. 1979 Sep;14(1):31-6. doi: 10.1016/0304-3940(79)95339-4.
The effects of bromocriptine and lisuride on cyclic AMP concentrations in homogenates and in intact slices of rat neostriatum were investigated. Significant increases in cyclic AMP concentration were found after a 10-min exposure to bromocriptine and lisuride in striatal intact slices. On the contrary, as previously found, the two dopaminergic ergot derivatives did not stimulate dopamine-senstiive adenylate cyclase present in striatal homogenates. The stimulatory effects observed only in intact tissues were blocked by the specific dopamine receptor blocking agent fluphenazine. It is tempting to conclude that dopaminergic ergot derivatives have a site of action different from that stimulated by classic dopamine agonists in tissue homogenates.
研究了溴隐亭和麦角乙脲对大鼠新纹状体匀浆和完整脑片中环磷酸腺苷（cAMP）浓度的影响。在纹状体完整脑片中，暴露于溴隐亭和麦角乙脲10分钟后，发现cAMP浓度显著升高。相反，如先前发现的那样，这两种多巴胺能麦角衍生物并未刺激纹状体匀浆中存在的多巴胺敏感性腺苷酸环化酶。仅在完整组织中观察到的刺激作用被特异性多巴胺受体阻断剂氟奋乃静所阻断。很容易得出结论，多巴胺能麦角衍生物的作用位点与经典多巴胺激动剂在组织匀浆中刺激的位点不同。
