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去甲肾上腺素和酪胺对猫离体大脑中动脉和股动脉作用的分析。

Analysis of the effects of noradrenaline and tyramine in isolated middle cerebral and femoral arteries of cat.

作者信息

Marín J, Salaices M, Sánchez C F

出版信息

Gen Pharmacol. 1982;13(2):125-32. doi: 10.1016/0306-3623(82)90067-2.

DOI:10.1016/0306-3623(82)90067-2
PMID:6807742
Abstract
  1. Tyramine and noradrenaline (NA) caused dose-dependent contractions in middle cerebral and femoral arteries of cat, which were decreased by phentolamine. 2. Gangliectomy increased the contraction evoked by NA in brain arteries. 3. Reserpine pretreatment and/or gangliectomy reduced the contraction caused by tyramine, the maximal responses being unmodified in the cerebral vessels. 4. Tyramine induced Ca2+-dependent tritium release from brain and femoral arteries, which was reduced by reserpine pretreatment and/or gangliectomy. 5. These data suggest that tyramine has a direct component, apart from an indirect one, in brain arteries. The mechanisms by which NA induces slight contraction in them, including the role of Ca2+, are postulated.
摘要
  1. 酪胺和去甲肾上腺素（NA）可引起猫大脑中动脉和股动脉剂量依赖性收缩，酚妥拉明可使其收缩减弱。2. 神经节切除增加了NA在脑动脉中诱发的收缩。3. 利血平预处理和/或神经节切除减少了酪胺引起的收缩，大脑血管中的最大反应未改变。4. 酪胺诱导大脑和股动脉释放Ca2+依赖性氚，利血平预处理和/或神经节切除可使其减少。5. 这些数据表明，酪胺在脑动脉中除了间接作用外，还有直接作用成分。推测了NA在其中诱导轻微收缩的机制，包括Ca2+的作用。

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1
Analysis of the effects of noradrenaline and tyramine in isolated middle cerebral and femoral arteries of cat.去甲肾上腺素和酪胺对猫离体大脑中动脉和股动脉作用的分析。
Gen Pharmacol. 1982;13(2):125-32. doi: 10.1016/0306-3623(82)90067-2.
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引用本文的文献

1
Effects of ouabain on isolated cerebral and femoral arteries of the cat: a functional and biochemical study.哇巴因对猫离体脑动脉和股动脉的影响：一项功能与生化研究。
Br J Pharmacol. 1988 Jan;93(1):43-52. doi: 10.1111/j.1476-5381.1988.tb11403.x.