Suzuki H, Seo F, Kanazawa M, Yanaihara T, Nakayama T, Kawai N
Nihon Sanka Fujinka Gakkai Zasshi. 1982 Jun;34(6):701-8.
Relationship between endometrial findings and serum hormone concentrations in patients with functional uterine bleeding (FUB) was not clarified yet. One hundred patients affected by FUB were divided into four groups according to their endometrial patterns: 1) proliferative phase(P), 2) secretary phase(S), 3) atrophic secretary phase(A-S) and 4) cystic glandular hyperplasia(C). Serum hormone levels which included LH, FSH, prolactine(PRL), estradiol and progesterone were measured by radioimmunoassay. 79% of the patients we studied were between 21 to 45 years and 21% were under 20 years or over 46 years of age. None of the patients received hormone therapy prior to the study. P(45%) and S(30%) were frequently encountered in histological manifestation of FUB while C was found no more than 4%. In 21% of the patients revealed apocrine resembled metaplasia of endometrium(AP), the cells resembled to the epithelium of apocrine sweat glands. This metaplasia was found in every endometrial patterns, but was seen in A-S most frequently. Serum concentrations of hormones in patients classified as C were characteristically and inclined to be hypergonadotropic and hypoestrogenic. High PRL levels were found in group S. All hormone levels except for FSH were statistically lower in the group of AP than that in groups where no AP was found.
功能性子宫出血（FUB）患者子宫内膜表现与血清激素浓度之间的关系尚未明确。100例FUB患者根据其子宫内膜形态分为四组：1）增殖期（P），2）分泌期（S），3）萎缩性分泌期（A-S）和4）囊性腺增生（C）。采用放射免疫分析法测定血清激素水平，包括促黄体生成素（LH）、促卵泡生成素（FSH）、催乳素（PRL）、雌二醇和孕酮。我们研究的患者中79%年龄在21至45岁之间，21%年龄在20岁以下或46岁以上。所有患者在研究前均未接受激素治疗。FUB的组织学表现中P（45%）和S（30%）最为常见，而C的比例不超过4%。21%的患者出现子宫内膜顶泌化生样改变（AP），细胞类似于顶泌汗腺上皮。这种化生在各种子宫内膜形态中均有发现，但在A-S中最为常见。分类为C的患者血清激素浓度具有特征性，倾向于高促性腺激素和低雌激素。S组中发现催乳素水平较高。除FSH外，AP组的所有激素水平在统计学上均低于未发现AP的组。
