West D B, Diaz J, Woods S C
J Nutr. 1982 Jul;112(7):1339-43. doi: 10.1093/jn/112.7.1339.
Female rat pups were overfed by continuous intragastric infusion of a milk formula from day 4 through day 128 postpartum. These rats dramatically accelerated weight gain after day 109. By day 18 the overfed pups weighted significantly more than both normally reared 18-day-old pups and pups reared artificially but maintained at the same growth rate as normally reared pups. On day 18 the catheters were removed from gastrostomized pups and normally reared pups were removed from their dams. Thereafter, all groups were maintained ad libitum on a standard diet. The body weights of overfed pups were still significantly greater than those of both other groups on day 120. The procedure provides an important new tool to examine the role of early nutrition in the etiology of obesity.
从产后第4天到第128天，通过持续胃内输注奶粉对雌性幼鼠进行过度喂养。这些大鼠在第109天后体重显著加速增加。到第18天时，过度喂养的幼鼠体重明显高于正常饲养的18日龄幼鼠以及人工饲养但生长速度与正常饲养幼鼠相同的幼鼠。在第18天，将胃造口幼鼠的导管移除，并将正常饲养的幼鼠与母鼠分开。此后，所有组均自由采食标准饮食。在第120天时，过度喂养幼鼠的体重仍显著高于其他两组。该方法为研究早期营养在肥胖病因学中的作用提供了一个重要的新工具。
