Lutz Thomas A, Woods Stephen C
University of Zurich, Institute of Veterinary Physiology, Zurich Center of Integrative Human Physiology, Zurich, Switzerland.
Curr Protoc Pharmacol. 2012 Sep;Chapter 5:Unit5.61. doi: 10.1002/0471141755.ph0561s58.
The focus of this overview is on the animal models of obesity most commonly utilized in research. The models include monogenic models in the leptin pathway, polygenic diet-dependent models, and, in particular for their historical perspective, surgical and chemical models of obesity. However, there are far too many models to consider all of them comprehensively, especially those caused by selective molecular genetic approaches modifying one or more genes in specific populations of cells. Further, the generation and use of inducible transgenic animals (induced knock-out or knock-in) is not covered, even though they often carry significant advantages compared to traditional transgenic animals, e.g., influences of the genetic modification during the development of the animals can be minimized. The number of these animal models is simply too large to be covered in this unit.
本综述的重点是研究中最常用的肥胖动物模型。这些模型包括瘦素途径中的单基因模型、多基因饮食依赖模型，特别是从历史角度来看的肥胖手术和化学模型。然而，模型数量太多，无法全面考虑所有模型，尤其是那些通过选择性分子遗传学方法在特定细胞群体中修饰一个或多个基因而导致的模型。此外，本单元不涉及诱导型转基因动物（诱导敲除或敲入）的产生和使用，尽管与传统转基因动物相比，它们通常具有显著优势，例如，可以将动物发育过程中基因修饰的影响降至最低。这些动物模型的数量实在太多，无法在本单元中涵盖。
