Mandyla H, Hatjidemitriou A, Tsingoglou S, Xanthou M
Padiatr Padol. 1982;17(2):201-9.
T. P. N. (aminoacids-glucose-fat) or aminoacids and glucose (A-G.) was given to 49 premature low-birth-weight neonates through peripheral veins for 7--42 days. The T. P. N. infusate contained glucose 12--20.5 g/kg/day and a standard dose of 2 g/kg/day for aminoacids and fat. The patients formed 4 groups: Twenty neonates were healthy but unable to tolerate oral feeding. Ten of them (group A) received T. P. N. and ten (Group B) received only A-G. Twenty nine neonates suffered from serious illness: 14 of them (Group C) received T. P. N. and 15 (Group D) A-G. In healthy neonates the weight gain was significantly higher in those who received T. P. N. than in those who took the same amount of calories but with A-G only. The addition of fat in parenteral nutrition is necessary in order to achieve a weight gain similar to that of intrauterine period. Fat is even more necessary in sick low-birth-weight neonates because they were found to be unable to tolerate high doses of glucose. Only part of the energy intake of the sick neonates could be covered with A-G. The present study has shown that parenteral nutrition can safely be given to sick low-birth-weight neonates without serious complications.
对49例早产低体重新生儿经外周静脉给予全胃肠外营养（氨基酸 - 葡萄糖 - 脂肪）或氨基酸加葡萄糖（A - G），持续7至42天。全胃肠外营养输注液含葡萄糖12至20.5克/千克/天，氨基酸和脂肪的标准剂量为2克/千克/天。患者分为4组：20例新生儿健康但不能耐受经口喂养。其中10例（A组）接受全胃肠外营养，10例（B组）仅接受氨基酸加葡萄糖。29例新生儿患有严重疾病：其中14例（C组）接受全胃肠外营养，15例（D组）接受氨基酸加葡萄糖。在健康新生儿中，接受全胃肠外营养者的体重增加显著高于摄入相同热量但仅接受氨基酸加葡萄糖者。肠外营养中添加脂肪对于实现与宫内时期相似的体重增加是必要的。脂肪对于患病的低体重新生儿更为必要，因为发现他们不能耐受高剂量葡萄糖。患病新生儿的能量摄入只有一部分可以通过氨基酸加葡萄糖来满足。本研究表明，肠外营养可以安全地给予患病的低体重新生儿，且无严重并发症。
