Ksir C
Psychopharmacologia. 1975 Jul 23;43(1):37-41. doi: 10.1007/BF00437612.
A parametric examination of the interaction between drug-induced behavioral changes and the degree of predrug stimulus control was conducted with rats. A discretetrial simultaneous discrimination was used, with the controlling stimuli varied over 6 values of distinctiveness. The effects of graded doses of scopolamine, d-amphetamine, and methylscopolamine on these performances were studied, with both scopolamine and d-amphetamine showing no increase in error rate under strong stimulus control, and dose-related increases in error rate under weak stimulus control. The similar interaction between drug effect and stimulus control for scopolamine and d-amphetamine indicates that the interaction reflects the degree of susceptibility of the behaviors to drug action, rather than two specific drug-behavior interactions. Methylscopolamine produced a slight effect on error rate and no significant interaction with stimulus control. A decrease in the number of trials responded to was found with both scopolamine and methylscopolamine, but not with d-amphetamine.
对大鼠进行了药物诱导的行为变化与给药前刺激控制程度之间相互作用的参数研究。采用离散试验同时辨别法，控制刺激在6个不同程度的值上变化。研究了不同剂量东莨菪碱、右旋苯丙胺和甲基东莨菪碱对这些行为表现的影响，结果显示，在强刺激控制下，东莨菪碱和右旋苯丙胺的错误率均未增加，而在弱刺激控制下，错误率与剂量相关增加。东莨菪碱和右旋苯丙胺在药物效应和刺激控制之间的相似相互作用表明，这种相互作用反映了行为对药物作用的敏感程度，而非两种特定的药物 - 行为相互作用。甲基东莨菪碱对错误率产生轻微影响，且与刺激控制无显著相互作用。发现东莨菪碱和甲基东莨菪碱处理后反应的试验次数均减少，但右旋苯丙胺处理后未出现这种情况。
