Rijke R P, van Dongen J M
Acta Histochem Suppl. 1980;21:81-9.
The small intestinal epithelium constitutes the cell renewing system with the largest turnover activity in the body. It is influenced by numerous factors, and has a great potential for adaptation. The control mechanisms responsible for the balance between cell production and cell loss in this system are still largely unknown. In this paper we present the hypothesis for two control mechanisms of crypt cell production. The first mechanism, the feedback control mechanism of crypt cell production by the functional villus cell population, regulates the relative size of the proliferative cell compartment in the crypt (i.e. the growth fraction), and it is a strictly local control mechanism. The second mechanism, the adaptive control mechanism of crypt cell reduction, regulates the total size of the crypt without changing the relative size of the proliferative cell compartment in the crypt. This control mechanism may act in a local as well as in a systemic way. Some of the problems encountered in studies on the control of crypt cell production in the small intestinal epithelium, are briefly discussed.
小肠上皮构成了体内更新活动最活跃的细胞更新系统。它受多种因素影响，具有很大的适应潜力。该系统中负责细胞生成与细胞丢失平衡的调控机制在很大程度上仍不为人知。在本文中，我们提出了隐窝细胞生成的两种调控机制的假说。第一种机制，即功能性绒毛细胞群体对隐窝细胞生成的反馈调控机制，调节隐窝中增殖细胞区室的相对大小（即生长分数），它是一种严格的局部调控机制。第二种机制，即隐窝细胞减少的适应性调控机制，调节隐窝的总体大小，而不改变隐窝中增殖细胞区室的相对大小。这种调控机制可能以局部和全身的方式起作用。本文简要讨论了在小肠上皮隐窝细胞生成调控研究中遇到的一些问题。
