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[痢疾志贺氏菌3 - 7血清型的抗原。IV. 外毒素的免疫化学研究]

[Antigens of Shigella dysenteriae serovars 3-7. IV. Immunochemical study of the exotoxin].

作者信息

Ianishevskaia M N

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1982 May(5):75-9.

PMID:6808792
Abstract

The exotoxins of Sh. dysenteriae, serovars 3 and 7, possess antigenic and serological properties and are characterized by the heterogeneous antigenic structure which distinctly differs from the structure of O-antigen in its immunochemical properties. These exotoxins consist of thermolabile and thermostable components. The thermolabile exotoxin fraction is a lethal toxin. The thermostable exotoxin fraction, obtained from the cultures of Sh. dysenteriae in the S-form, corresponds to O-antigen and forms an insignificant admixture in the concentrated exotoxins. The thermostable fraction of the exotoxins of S--R mutants differs from O-antigen by its serological specificity.

摘要

痢疾志贺氏菌3型和7型的外毒素具有抗原性和血清学特性,其特征在于异质性抗原结构,在免疫化学性质上与O抗原的结构明显不同。这些外毒素由不耐热和耐热成分组成。不耐热外毒素部分是一种致死毒素。从S型痢疾志贺氏菌培养物中获得的耐热外毒素部分与O抗原相对应,在浓缩外毒素中形成少量混合物。S-R突变体外毒素的耐热部分在血清学特异性上与O抗原不同。

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