Lopez J M
Arch Microbiol. 1982 May;131(3):247-51. doi: 10.1007/BF00405887.
After addition of amino acids to a Bacillus subtilis glucose culture the intracellular guanosine triphosphate (GTP) concentration increased. The growth rate and the rate of RNA accumulation increased too. With mycophenolic acid, an inhibitor of inosinate dehydrogenase, it was possible to adjust the intracellular GTP concentration to values ranging between that of the glucose culture and that of the culture which had received amino acids. This led to intermediate growth rate values. Guanosine abolished the mycophenolic acid inhibition of GTP synthesis. It also counteracted the drug effects on growth rate and RNA accumulation. In cultures growing on Nutrient Sporulation Medium, in which the growth rate decreases as cell density increases, the GTP concentration did correlate with the growth rate.
向枯草芽孢杆菌葡萄糖培养物中添加氨基酸后，细胞内三磷酸鸟苷（GTP）浓度升高。生长速率和RNA积累速率也随之增加。使用肌苷酸脱氢酶抑制剂霉酚酸，可以将细胞内GTP浓度调节到介于葡萄糖培养物和已添加氨基酸的培养物之间的值。这导致了中间生长速率值。鸟苷消除了霉酚酸对GTP合成的抑制作用。它还抵消了药物对生长速率和RNA积累的影响。在营养芽孢形成培养基上生长的培养物中，生长速率随着细胞密度的增加而降低，GTP浓度确实与生长速率相关。
