Ehrenthal W, Rochel M
Arzneimittelforschung. 1982;32(4):449-52.
Drug monitoring for valproic acid (Convulex) was performed in 200 children with a newly developed HPLC procedure and in part with an enzyme immunoassay (EMIT). In addition the activities of the transaminases and the lipase were determined as well as platelet count, prothrombin time, thrombin time, partial thromboplastin time, fibrinogen concentration and in some cases the coagulation factors II, V and X. There is not a higher frequency for pathological laboratory findings with higher serum levels. 81 children exhibited pathological findings, however only in one case therapy had to be stopped. Recommendations when to stop therapy are given.
采用新开发的高效液相色谱法（HPLC）并部分结合酶免疫分析法（EMIT）对200名儿童进行了丙戊酸（Convulex）药物监测。此外，还测定了转氨酶和脂肪酶的活性以及血小板计数、凝血酶原时间、凝血酶时间、部分凝血活酶时间、纤维蛋白原浓度，部分病例还测定了凝血因子II、V和X。血清水平较高时，病理实验室检查结果的发生率并未更高。81名儿童有病理检查结果，但只有1例必须停药。文中给出了何时停药的建议。
