Vinçon G, Demotes-Mainard F, Bistue C, Jarry C, Brachet-Liermain A, Albin H
Ann Biol Clin (Paris). 1984;42(6):427-32.
Theophylline, phenobarbitol, and valproic acid serum levels were measured from plasma samples using chromatographic (HPLC and GC) and by immunologic techniques using enzyme kinetics (EMIT) or fluorescence polarization (FPIA). Results of these various methods differ when examined by more stringent statistical analysis. These differences do not appear to be clinically important except possibly for valproic acid the case in employing immunologic methods as well as their rapidity render these techniques particularly useful for therapeutic surveillance.
采用色谱法（高效液相色谱法和气相色谱法）以及免疫技术（酶动力学免疫分析法和荧光偏振免疫分析法）测定血浆样本中的茶碱、苯巴比妥和丙戊酸血清水平。当通过更严格的统计分析进行检验时，这些不同方法的结果存在差异。除了丙戊酸外，这些差异似乎在临床上并不重要。采用免疫方法的情况以及其快速性使得这些技术对治疗监测特别有用。
