Brock N, Stekar J
Arzneimittelforschung. 1982;32(5):486-7.
Sodium 2-mercaptoethane sulfonate (mesna, Uromitexan) is oxidized in the organism of rats to 2,2'-dithiodi-(ethane sodium sulfonate) (dimesna). Dimesna is partially reduced to the mercapto compound mesna (kidneys); both compounds are eliminated via the urine. Even after administration of dimesna mesna can be detected in the urine. Accordingly dimesna also proved to be an effective antidote against the urotoxic actions of cyclophosphamide and ifosfamide.
2-巯基乙烷磺酸钠（美司钠，Uromitexan）在大鼠体内被氧化为2,2'-二硫代二（乙烷磺酸钠）（二巯基丁二酸钠）。二巯基丁二酸钠部分还原为巯基化合物美司钠（肾脏）；两种化合物均通过尿液排出。即使给予二巯基丁二酸钠后，尿液中仍可检测到美司钠。因此，二巯基丁二酸钠也被证明是一种有效的抗环磷酰胺和异环磷酰胺尿路毒性作用的解毒剂。
