Schmähl D, Habs M, Tacchi A M
Urologe A. 1984 Sep;23(5):291-6.
An experimental model was developed, in which urinary bladder cancer was induced by cyclophosphamide in rats, thus reproducing cyclophosphamide-induced urinary bladder carcinogenesis observed in humans. It was possible in this model to achieve a highly significant reduction of cyclophosphamide-induced urinary bladder cancer by concomitant administration of sodium 2-mercaptoethane sulfonate (mesna). A significant delay of urinary bladder carcinogenesis by administration of the uroprotective substance mesna was also observed when using butylbutanolnitrosamine for inducing urinary bladder cancer. It was thus for the first time possible to assure chemoprevention of this tumor type by administration of a specific antidote.
建立了一种实验模型，其中用环磷酰胺诱导大鼠膀胱癌，从而再现了在人类中观察到的环磷酰胺诱导的膀胱癌发生过程。在该模型中，通过同时给予2-巯基乙烷磺酸钠（美司钠），可以使环磷酰胺诱导的膀胱癌显著减少。当使用丁基丁醇亚硝胺诱导膀胱癌时，也观察到给予尿保护物质美司钠可显著延迟膀胱癌的发生。因此，首次有可能通过给予特定解毒剂来确保对这种肿瘤类型进行化学预防。
