Hamminga L, Hermans J, Noordijk E M, Meijer C J, Scheffer E, Van Vloten W A
Br J Dermatol. 1982 Aug;107(2):145-55. doi: 10.1111/j.1365-2133.1982.tb00332.x.
Clinicopathological findings, methods of treatment and survival in ninety-two patients with cutaneous T-cell lymphoma (CTCL) (eighty-five mycosis fungoides and seven Sézary syndrome), seen in the Leiden University Hospital between 1974 and 1980, are reported. All patients were staged and treatment was given accordingly. Patients without signs of extracutaneous disease (74%) were treated with eigher total-skin electron-beam irradiation (E beam), topical mechlorethamine (HN2) or PUVA. Topical HN2 and E beam had an equal effect on survival. Electron-beam induced a higher number of initial complete remissions than HN2, but fewer patients relapsed while on maintenance treatment with HN2. In the patients with lymph node and/or visceral involvement, E beam followed by systemic chemotherapy--cyclophosphamide, vincristin (Oncovin) and prednisone (COP)--gave better results than topical therapy or COP alone. Survival was influenced most by the type of skin lesion, the presence or absence of lymph node and/or visceral involvement, and the ability to induce a complete remission initially.
报告了1974年至1980年期间在莱顿大学医院就诊的92例皮肤T细胞淋巴瘤（CTCL）患者（85例蕈样肉芽肿和7例塞扎里综合征）的临床病理特征、治疗方法和生存率。所有患者均进行了分期，并据此给予治疗。无皮肤外疾病迹象的患者（74%）接受了全皮肤电子束照射（E束）、局部氮芥（HN2）或补骨脂素加紫外线A（PUVA）治疗。局部HN2和E束对生存率的影响相同。电子束诱导的初始完全缓解率高于HN2，但在接受HN2维持治疗时复发的患者较少。对于有淋巴结和/或内脏受累的患者，E束后进行全身化疗——环磷酰胺、长春新碱（Oncovin）和泼尼松（COP）——比单纯局部治疗或COP效果更好。生存率受皮肤病变类型、有无淋巴结和/或内脏受累以及最初诱导完全缓解的能力影响最大。
