渗透性血脑屏障破坏：犬类药效学研究及恶性脑肿瘤患者的临床I期试验
Osmotic blood-brain barrier disruption: pharmacodynamic studies in dogs and a clinical phase I trial in patients with malignant brain tumors.
作者信息
Neuwelt E A, Hill S A, Frenkel E P, Diehl J T, Maravilla K R, Vu L H, Clark W K, Rapoport S I, Barnett P A, Lewis S E, Ehle A L, Beyer C W
出版信息
Cancer Treat Rep. 1981;65 Suppl 2:39-43.
Infusion of 25% mannitol in saline into the internal carotid artery of dogs disrupts the blood-brain barrier (BBB) in a controlled and reproducible manner (osmotic disruption), whereas mannitol infused through the common carotid artery produces variable disruption of the BBB. Compared to controls, infusion of methotrexate in dogs after osmotic disruption produced significantly higher drug levels in brain. We report very preliminary data on the effects of osmotic disruption with mannitol in five patients harboring malignant brain tumors.
向狗的颈内动脉输注25%的甘露醇生理盐水能以可控且可重复的方式（渗透性破坏）破坏血脑屏障（BBB），而通过颈总动脉输注甘露醇对血脑屏障的破坏则具有变异性。与对照组相比，在渗透性破坏后向狗输注甲氨蝶呤可使脑内药物水平显著升高。我们报告了关于甘露醇渗透性破坏对五例患有恶性脑肿瘤患者影响的非常初步的数据。
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