Maral R J, Jouanne M
Cancer Treat Rep. 1981;65 Suppl 4:9-18.
The toxic effects of daunorubicin with specific reference to acute, subacute, and long-term studies in animals are reviewed, and its clinical toxicity is considered. We emphasize the importance of hematologic toxicity and infections when treating with daunorubicin. A summary of the work done on detoxifying activities of certain compounds is presented, and the activities that increase the toxic effects of daunorubicin are discussed. Finally, the immunosuppressive, mutagenic, teratogenic, and carcinogenic activities of daunorubicin are mentioned.
本文综述了柔红霉素的毒性作用，特别提及了在动物身上进行的急性、亚急性和长期研究，并探讨了其临床毒性。我们强调了在使用柔红霉素治疗时血液学毒性和感染的重要性。文中还总结了某些化合物解毒活性的研究工作，并讨论了增强柔红霉素毒性作用的活性。最后，还提到了柔红霉素的免疫抑制、致突变、致畸和致癌活性。
